In recent years, Software Supply Chain (SSC) security issues have frequently occurred, which has brought great challenges to software security research. Since there are millions of new software released every day, it is essential to detect the pollution of SSC automatically. The problem of SSC pollution was first analyzed and discussed. Then focusing on the requirements of pollution detection in the downstream of SSC, the automatic program reverse analysis methods and their applications in the SSC pollution detection was introduced. Finally, the shortcomings and challenges faced by the existing technologies in solving the problem of SSC pollution was summarized and analyzed, and some researches worth studying to overcome these challenges were pointed out.